› 4ldb

X-ray diffraction
3.1Å resolution

Crystal Structure of Ebola Virus VP40 Dimer

Released:
DOI: 10.2210/pdb4ldb/pdb
PDB entry 4ldb coloured by chain, front view.
PDB entry 4ldb coloured by chain, side view.
PDB entry 4ldb coloured by chain, top view.
Source organism: Zaire ebolavirus
Primary publication:
Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle.
Bornholdt ZA, Noda T, Abelson DM, Halfmann P, Wood MR, Kawaoka Y, Saphire EO
Cell 154 763-74 (2013)
PMID: 23953110

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170148 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein VP40 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 297 amino acids
Theoretical weight: 32.24 KDa
Source organism: Zaire ebolavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05128 (Residues: 44-326; Coverage: 87%)
Gene name: VP40
Sequence domains: Matrix protein VP40
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P62
Unit cell:
a: 160.005Å b: 160.005Å c: 89.745Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.245 0.282
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Cell cycle regulation during viral infection.
Bagga et al. (2014)
32 more

21 mentions without citation

Oligomeric viral proteins: small in size, large in presence.
Jayaraman et al. (2016)
20 more