PDBe 4l9m

X-ray diffraction
3Å resolution

Autoinhibited state of the Ras-specific exchange factor RasGRP1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAS guanyl-releasing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 559 amino acids
Theoretical weight: 64.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95267 (Residues: 50-607; Coverage: 70%)
Gene names: RASGRP, RASGRP1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P6122
Unit cell:
a: 76.38Å b: 76.38Å c: 408.37Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.224 0.269
Expression system: Escherichia coli