PDBe 4l7x

X-ray diffraction
1.35Å resolution

Crystal structure of the DIDO PHD finger in complex with H3K4me3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Death-inducer obliterator 1 Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 7.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q9BTC0 (Residues: 266-325; Coverage: 3%)
Gene names: C20orf158, DATF1, DIDO1, KIAA0333
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)
Histone H3.1 Chain: U
Molecule details ›
Chain: U
Length: 12 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P68431 (Residues: 2-13; Coverage: 9%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P41212
Unit cell:
a: 40.82Å b: 40.82Å c: 80.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.14 0.132 0.142
Expression systems:
  • Escherichia coli
  • Not provided