PDBe 4l3o

X-ray diffraction
2.52Å resolution

Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase sirtuin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 302 amino acids
Theoretical weight: 34.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IXJ6 (Residues: 55-356; Coverage: 78%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:
cyclic peptide S2iL5 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 16 amino acids
Theoretical weight: 2.04 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P212121
Unit cell:
a: 91.18Å b: 135.613Å c: 148.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.211 0.263
Expression systems:
  • Escherichia coli
  • Not provided