PDBe 4l23

X-ray diffraction
2.5Å resolution

Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 324 amino acids
Theoretical weight: 39.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P27986 (Residues: 318-615; Coverage: 41%)
  • Best match: P27986-5 (Residues: 1-252)
Gene names: GRB1, PIK3R1
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 71.628Å b: 136.377Å c: 151.487Å
α: 90° β: 90° γ: 90°
R R work R free
0.218 0.215 0.273
Expression system: Spodoptera frugiperda