PDBe 4l00

X-ray diffraction
1.8Å resolution

Crystal structure of the apo Jak1 pseudokinase domain


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: NEW P23458 (Residues: 561-860; Coverage: 26%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 47.026Å b: 80.656Å c: 76.231Å
α: 90° β: 95.44° γ: 90°
R R work R free
0.171 0.169 0.203
Expression system: Not provided