PDBe 4kxy

X-ray diffraction
1.26Å resolution

Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP


Function and Biology Details

Reaction catalysed:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transketolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 637 amino acids
Theoretical weight: 69.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P29401 (Residues: 1-623; Coverage: 100%)
Gene name: TKT
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand 1U0 2 x 1U0

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 73.15Å b: 86.05Å c: 92.73Å
α: 90° β: 94.12° γ: 90°
R R work R free
0.165 0.154 0.204
Expression system: Escherichia coli BL21(DE3)