PDBe 4kvp

X-ray diffraction
1.5Å resolution

Human p53 Core Domain Mutant V157F

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 220 amino acids
Theoretical weight: 24.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04637 (Residues: 94-312; Coverage: 56%)
  • Best match: P04637-9 (Residues: 1-180)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P21
Unit cell:
a: 68.656Å b: 70.279Å c: 83.559Å
α: 90° β: 90.06° γ: 90°
R-values:
R R work R free
0.176 0.174 0.21
Expression system: Escherichia coli BL21(DE3)