PDBe 4kv4

X-ray diffraction
2Å resolution

Brd4 Bromodomain 2 in Complex with Acetylated Rel Peptide


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O60885 (Residues: 351-459; Coverage: 8%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like
Transcription factor p65 Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 897 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q04206 (Residues: 308-314; Coverage: 1%)
Gene names: NFKB3, RELA

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21212
Unit cell:
a: 57.026Å b: 73.599Å c: 33.626Å
α: 90° β: 90° γ: 90°
R R work R free
0.21 0.208 0.258
Expression systems:
  • Escherichia coli
  • Not provided