PDBe 4k33

X-ray diffraction
2.34Å resolution

Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Fibroblast growth factor receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: NEW P22607 (Residues: 449-759; Coverage: 40%)
Gene names: FGFR3, JTK4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P212121
Unit cell:
a: 54.226Å b: 61.427Å c: 100.666Å
α: 90° β: 90° γ: 90°
R R work R free
0.181 0.176 0.228
Expression system: Escherichia coli