PDBe 4jfn

X-ray diffraction
1.75Å resolution

Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
N-APP Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P05067 (Residues: 23-185; Coverage: 22%)
Gene names: A4, AD1, APP
Sequence domains: Amyloid A4 N-terminal heparin-binding
Structure domains: Amyloidogenic glycoprotein, heparin-binding domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 34.05Å b: 49.07Å c: 66.16Å
α: 90° β: 90° γ: 90°
R R work R free
0.183 0.181 0.23
Expression system: Escherichia coli