PDBe 4ja8

X-ray diffraction
1.55Å resolution

Function and Biology Details

Reaction catalysed:
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isocitrate dehydrogenase [NADP], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 416 amino acids
Theoretical weight: 47.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P48735 (Residues: 41-452; Coverage: 91%)
Gene name: IDH2
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Structure domains: Isopropylmalate Dehydrogenase

Ligands and Environments


Cofactor: Ligand NDP 2 x NDP
3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 58.656Å b: 119.661Å c: 125.542Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.218
Expression system: Not provided