PDBe 4j9f

X-ray diffraction
1.09Å resolution

Crystal structure of the Abl-SH3 domain complexed with the high affinity peptide P0

Released:
Source organism: Homo sapiens
Entry author: Camara-Artigas A

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ABL1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 63 amino acids
Theoretical weight: 7.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00519 (Residues: 60-121; Coverage: 6%)
Gene names: ABL, ABL1, JTK7
Sequence domains: SH3 domain
Structure domains: SH3 Domains
SH3 domain-binding protein 1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 11 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y3L3 (Residues: 616-625; Coverage: 1%)
  • Best match: Q9Y3L3-2 (Residues: 391-393)
Gene name: SH3BP1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3221
Unit cell:
a: 86.429Å b: 86.429Å c: 45.16Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.148 0.147 0.169
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided