PDBe 4j9d

X-ray diffraction
1.5Å resolution

Crystal structure of the N114A mutant of the Abl-SH3 domain complexed with the high affinity peptide P0

Released:
Source organism: Homo sapiens
Entry author: Camara-Artigas A

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ABL1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 63 amino acids
Theoretical weight: 6.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00519 (Residues: 60-121; Coverage: 6%)
Gene names: ABL, ABL1, JTK7
Sequence domains: SH3 domain
Structure domains: SH3 Domains
SH3 domain-binding protein 1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 11 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y3L3 (Residues: 616-625; Coverage: 1%)
  • Best match: Q9Y3L3-2 (Residues: 391-393)
Gene name: SH3BP1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3221
Unit cell:
a: 86.38Å b: 86.38Å c: 44.95Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.145 0.143 0.183
Expression systems:
  • Escherichia coli
  • Not provided