PDBe 4j6g

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero 12-mer
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 14, soluble form Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.19 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O43557 (Residues: 83-240; Coverage: 66%)
Gene names: HVEML, LIGHT, TNFSF14, UNQ391/PRO726
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 6B Chains: C, D
Molecule details ›
Chains: C, D
Length: 174 amino acids
Theoretical weight: 19.04 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O95407 (Residues: 30-195; Coverage: 61%)
Gene names: DCR3, TNFRSF6B, TR6, UNQ186/PRO212
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P213
Unit cell:
a: 149.058Å b: 149.058Å c: 149.058Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.232
Expression system: Drosophila