PDBe 4iyp

X-ray diffraction
2.8Å resolution

structure of the nPP2Ac-alpha4 complex

Released:

Function and Biology Details

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 222 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78318 (Residues: 2-234; Coverage: 65%)
Gene names: IBP1, IGBP1
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Chain: C
Molecule details ›
Chain: C
Length: 151 amino acids
Theoretical weight: 17.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P67775 (Residues: 6-153; Coverage: 48%)
Gene name: PPP2CA
Structure domains: Purple Acid Phosphatase; chain A, domain 2

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P3221
Unit cell:
a: 116.127Å b: 116.127Å c: 81.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.179 0.222
Expression system: Escherichia coli