PDBe 4iwv

X-ray diffraction
2.1Å resolution

Crystals structure of Human Glucokinase in complex with small molecule activator

Released:
Source organism: Homo sapiens
Entry authors: Ogg DJ, Hargreaves D, Gerhardt S, Flavell L, McAlister M

Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase Chain: A
Molecule details ›
Chain: A
Length: 456 amino acids
Theoretical weight: 50.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 15-465; Coverage: 97%)
  • Best match: P35557-3 (Residues: 12-464)
Gene name: GCK
Sequence domains:
Structure domains: Hexokinase; domain 1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P41
Unit cell:
a: 77.938Å b: 77.938Å c: 85.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.25
Expression system: Escherichia coli