PDBe 4is6

X-ray diffraction
2.5Å resolution

Crystal structure of HLA-DR4 bound to GP100 peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
M-alpha Chain: C
Molecule details ›
Chain: C
Length: 16 amino acids
Theoretical weight: 2.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P40967 (Residues: 44-59; Coverage: 3%)
Gene names: D12S53E, PMEL, PMEL17, SILV
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-4 beta chain Chain: B
Molecule details ›
Chain: B
Length: 192 amino acids
Theoretical weight: 22.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13760 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 90.29Å b: 117.59Å c: 41.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.265 0.298
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)