PDBe 4ip7

X-ray diffraction
1.8Å resolution

Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and FBP.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKLR Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 543 amino acids
Theoretical weight: 58.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30613 (Residues: 34-574; Coverage: 94%)
  • Best match: P30613-2 (Residues: 1-543)
Gene names: PK1, PKL, PKLR
Sequence domains:
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 78.14Å b: 205.078Å c: 83.91Å
α: 90° β: 92.15° γ: 90°
R-values:
R R work R free
0.189 0.187 0.226
Expression system: Escherichia coli