PDBe 4ijt

X-ray diffraction
1.78Å resolution

Human p53 core domain with hot spot mutation R273H (form II)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04637 (Residues: 94-293; Coverage: 51%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P61
Unit cell:
a: 74.937Å b: 74.937Å c: 73.308Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.162 0.194
Expression system: Escherichia coli BL21(DE3)