PDBe 4ifn

X-ray diffraction
2.4Å resolution

Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Kelch-like ECH-associated protein 1 Chain: X
Molecule details ›
Chain: X
Length: 291 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q14145 (Residues: 321-609; Coverage: 46%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 124.878Å b: 75.258Å c: 48.754Å
α: 90° β: 106.34° γ: 90°
R R work R free
0.278 0.274 0.352
Expression system: Escherichia coli