PDBe 4ifl

X-ray diffraction
1.8Å resolution

Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chain: X
Molecule details ›
Chain: X
Length: 291 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 321-609; Coverage: 46%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller
Nuclear factor erythroid 2-related factor 2 Chain: P
Molecule details ›
Chain: P
Length: 16 amino acids
Theoretical weight: 1.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16236 (Residues: 69-84; Coverage: 3%)
Gene names: NFE2L2, NRF2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21212
Unit cell:
a: 77.499Å b: 92.03Å c: 46.158Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.235
Expression systems:
  • Escherichia coli
  • Not provided