PDBe 4ifj

X-ray diffraction
1.8Å resolution

Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes

Released:
Source organism: Homo sapiens
Entry authors: Pan H, Lin M, Yang Y, Callaway K, Baker J, Diep L, Yan J, Tanaka K, Zhu YL, Konradi AW, Jobling M, Tam D, Ren Z, Cheung H, Bova M, Riley BE, Yao N, Artis DR

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 321-609; Coverage: 46%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6522
Unit cell:
a: 85.789Å b: 85.789Å c: 146.284Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.233
Expression system: Escherichia coli