PDBe 4ibm

X-ray diffraction
1.8Å resolution

Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06213 (Residues: 1005-1310; Coverage: 23%)
Gene name: INSR
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P212121
Unit cell:
a: 50.838Å b: 89.21Å c: 142.193Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.218
Expression system: Spodoptera frugiperda