PDBe 4i77

X-ray diffraction
1.9Å resolution

Lebrikizumab Fab bound to IL-13

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 Chain: Z
Molecule details ›
Chain: Z
Length: 112 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35225 (Residues: 35-146; Coverage: 100%)
Gene names: IL13, NC30
Structure domains: Growth Hormone; Chain: A;
Lebrikizumab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 219 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Lebrikizumab light chain Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 23.86 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 83.722Å b: 64.772Å c: 117.101Å
α: 90° β: 106.09° γ: 90°
R-values:
R R work R free
0.18 0.179 0.219
Expression systems:
  • Escherichia coli
  • Cricetulus griseus