PDBe 4i6j

X-ray diffraction
2.7Å resolution

A ubiquitin ligase-substrate complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cryptochrome-2 Chain: A
Molecule details ›
Chain: A
Length: 544 amino acids
Theoretical weight: 61.84 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9R194 (Residues: 1-544; Coverage: 92%)
Gene names: Cry2, Kiaa0658
Sequence domains:
Structure domains:
F-box/LRR-repeat protein 3 Chain: B
Molecule details ›
Chain: B
Length: 428 amino acids
Theoretical weight: 48.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UKT7 (Residues: 1-428; Coverage: 100%)
Gene names: FBL3A, FBXL3, FBXL3A
Sequence domains: F-box-like
Structure domains:
S-phase kinase-associated protein 1 Chain: C
Molecule details ›
Chain: C
Length: 163 amino acids
Theoretical weight: 18.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63208 (Residues: 1-163; Coverage: 100%)
Gene names: EMC19, OCP2, SKP1, SKP1A, TCEB1L
Sequence domains:
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3121
Unit cell:
a: 125.389Å b: 125.389Å c: 145.712Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.203 0.265
Expression system: Spodoptera frugiperda