4i3r

X-ray diffraction
3Å resolution

Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-212259 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 190 amino acids
Theoretical weight: 20.77 KDa
Source organism: Human immunodeficiency virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q3ZLH8 (Residues: 248-475; Coverage: 22%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Heavy chain of VRC-PG04 Fab Chain: H
Molecule details ›
Chain: H
Length: 228 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Light chain of VRC-PG04 Fab Chain: L
Molecule details ›
Chain: L
Length: 208 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 158.91Å b: 158.91Å c: 80.27Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.183 0.245
Expression system: Homo sapiens