PDBe 4hzh

X-ray diffraction
3.3Å resolution

Structure of recombinant Gla-domainless prothrombin mutant S525A

Released:

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prothrombin Chains: A, B
Molecule details ›
Chains: A, B
Length: 533 amino acids
Theoretical weight: 60.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 90-622; Coverage: 89%)
Gene name: F2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 82.584Å b: 103.136Å c: 149.549Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.296 0.295 0.329
Expression system: Homo sapiens