PDBe 4hva

X-ray diffraction
2.07Å resolution

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Caspase-6 subunit p18 Chains: A, B
Molecule details ›
Chains: A, B
Length: 265 amino acids
Theoretical weight: 30.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55212 (Residues: 24-293; Coverage: 87%)
Gene names: CASP6, MCH2
Sequence domains: Caspase domain
Structure domains: Rossmann fold
VEID Inhibitor Chains: C, D
Molecule details ›
Chains: C, D
Length: 5 amino acids
Theoretical weight: 789 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P21
Unit cell:
a: 55.988Å b: 62.647Å c: 76.298Å
α: 90° β: 104.79° γ: 90°
R-values:
R R work R free
0.174 0.172 0.214
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided