PDBe 4hix

X-ray diffraction
2.2Å resolution

Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
P3(42) Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-699; Coverage: 4%)
Gene names: A4, AD1, APP
Immunoglobulin heavy constant gamma 1 Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01857 (Residues: 1-107; Coverage: 32%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Unit cell:
a: 59.343Å b: 83.039Å c: 91.224Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.17 0.22
Expression system: Not provided