PDBe 4hcr

X-ray diffraction
2.3Å resolution

Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659

Released:
Source organism: Homo sapiens
Entry authors: Springer T, Yu Y, Zhu J

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
PF-547659 heavy chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 229 amino acids
Theoretical weight: 24.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
PF-547659 light chain Chains: L, N
Molecule details ›
Chains: L, N
Length: 219 amino acids
Theoretical weight: 24.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Mucosal addressin cell adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 22.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13477 (Residues: 23-225; Coverage: 56%)
Gene name: MADCAM1
Sequence domains: Adhesion molecule, immunoglobulin-like
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 39.94Å b: 112.26Å c: 157.92Å
α: 90° β: 89.95° γ: 90°
R-values:
R R work R free
0.158 0.154 0.208
Expression system: Homo sapiens