PDBe 4ggc

X-ray diffraction
1.35Å resolution

Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C

Source organism: Homo sapiens
Primary publication:
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc. Natl. Acad. Sci. U.S.A. (2012)
PMID: 23091007

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cell division cycle protein 20 homolog Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 34.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q12834 (Residues: 161-477; Coverage: 64%)
Gene name: CDC20
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 41.281Å b: 86.933Å c: 48.339Å
α: 90° β: 112.97° γ: 90°
R R work R free
0.133 0.132 0.146
Expression system: Spodoptera frugiperda