PDBe 4gfm

X-ray diffraction
2.3Å resolution

JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 35.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O60674 (Residues: 833-1132; Coverage: 27%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2221
Unit cell:
a: 93.094Å b: 102.084Å c: 67.754Å
α: 90° β: 90° γ: 90°
R R work R free
0.171 0.168 0.242
Expression system: Spodoptera frugiperda