› 4gc5

X-ray diffraction
1.8Å resolution

Crystal structure of murine TFB1M

Released:
DOI: 10.2210/pdb4gc5/pdb
PDB entry 4gc5 coloured by chain, front view.
PDB entry 4gc5 coloured by chain, side view.
PDB entry 4gc5 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1.
Guja KE, Venkataraman K, Yakubovskaya E, Shi H, Mejia E, Hambardjieva E, Karzai AW, Garcia-Diaz M
Nucleic Acids Res 41 7947-59 (2013)
PMID: 23804760

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dimethyladenosine transferase 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 345 amino acids
Theoretical weight: 39.35 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8JZM0 (Residues: 1-345; Coverage: 100%)
Gene name: Tfb1m
Sequence domains: Ribosomal RNA adenine dimethylase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ACT 2 x ACT
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: I222
Unit cell:
a: 47.63Å b: 101.27Å c: 211.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.224
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Maintenance and Expression of Mammalian Mitochondrial DNA.
Gustafsson et al. (2016)
4 more

5 mentions without citation

A model for transcription initiation in human mitochondria.
Morozov et al. (2015)
4 more