PDBe 4g69

X-ray diffraction
2Å resolution

Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disks large homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 10.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q12959 (Residues: 310-407; Coverage: 11%)
Gene name: DLG1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Adenomatous polyposis coli protein Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P25054 (Residues: 2833-2843; Coverage: 0%)
Gene names: APC, DP2.5

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 27.109Å b: 51.184Å c: 71.756Å
α: 90° β: 90° γ: 90°
R R work R free
0.172 0.171 0.183
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided