PDBe 4g1m

X-ray diffraction
2.9Å resolution

Re-refinement of alpha V beta 3 structure

Released:
Source organism: Homo sapiens
Primary publication:
α(V)β(3) Integrin Crystal Structures and Their Functional Implications.
Biochemistry 51 8814-28 (2012)
PMID: 23106217

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 959 amino acids
Theoretical weight: 106.05 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: NEW P06756 (Residues: 31-989; Coverage: 94%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: NEW P05106 (Residues: 27-718; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 129.87Å b: 129.87Å c: 305.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.179 0.233
Expression system: Cricetulus griseus