PDBe 4fxk

X-ray diffraction
3.6Å resolution

Human complement C4

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C4 beta chain Chain: A
Molecule details ›
Chain: A
Length: 656 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 20-675; Coverage: 38%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Structure domains:
Complement C4-A alpha chain Chain: B
Molecule details ›
Chain: B
Length: 767 amino acids
Theoretical weight: 84.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 680-1446; Coverage: 45%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Structure domains:
Complement C4 gamma chain Chain: C
Molecule details ›
Chain: C
Length: 291 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 1454-1744; Coverage: 17%)
Gene names: C4A, CO4, CPAMD2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29, SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 85.45Å b: 103.31Å c: 256.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.2 0.269