PDBe 4fuh

X-ray diffraction
1.6Å resolution

Crystal Structure of the Urokinase

Released:
Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA, Nienaber V, Giranda V

Function and Biology Details

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator chain B Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 27.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW P00749 (Residues: 179-424; Coverage: 60%)
Gene name: PLAU
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 54.7Å b: 53.4Å c: 80.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.144 0.183
Expression system: Escherichia coli