PDBe 4fsw

X-ray diffraction
2.3Å resolution

Crystal Structure of the CHK1

Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA, Chang P, Russell AJ

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: O14757 (Residues: 2-280; Coverage: 59%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 45.227Å b: 65.845Å c: 58.079Å
α: 90° β: 94.64° γ: 90°
R R work R free
0.185 0.184 0.212
Expression system: Homo sapiens