PDBe 4fsq

X-ray diffraction
2.4Å resolution

Crystal Structure of the CHK1

Released:
Source organism: Homo sapiens
Entry authors: Kang YN, Stuckey JA, Chang P, Russell AJ

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14757 (Residues: 2-280; Coverage: 59%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 45.365Å b: 65.989Å c: 58.295Å
α: 90° β: 94.55° γ: 90°
R-values:
R R work R free
0.177 0.175 0.216
Expression system: Homo sapiens