PDBe 4fpa

X-ray diffraction
2.48Å resolution

Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate

Released:
Source organism: Homo sapiens
Entry authors: Shen L, Honzatko RB

Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 917 amino acids
Theoretical weight: 102.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19367 (Residues: 1-917; Coverage: 100%)
Gene name: HK1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 82.607Å b: 121.14Å c: 119.888Å
α: 90° β: 92.69° γ: 90°
R-values:
R R work R free
0.256 0.238 0.256
Expression system: Escherichia coli