PDBe 4foi

X-ray diffraction
2.4Å resolution

Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate

Source organism: Homo sapiens
Entry authors: Shen L, Honzatko RB

Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hexokinase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 917 amino acids
Theoretical weight: 102.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P19367 (Residues: 1-917; Coverage: 100%)
Gene name: HK1
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 82.38Å b: 120.772Å c: 120.591Å
α: 90° β: 92.8° γ: 90°
R R work R free
0.273 0.247 0.273
Expression system: Escherichia coli