PDBe 4fli

X-ray diffraction
1.55Å resolution

Human MetAP1 with bengamide analog Y16, in Mn form

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Methionine aminopeptidase 1 Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 36.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: NEW P53582 (Residues: 81-386; Coverage: 79%)
Gene names: KIAA0094, METAP1
Sequence domains: Metallopeptidase family M24
Structure domains: Creatinase/methionine aminopeptidase superfamily

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 47.771Å b: 77.562Å c: 48.811Å
α: 90° β: 90.18° γ: 90°
R R work R free
0.184 0.183 0.211
Expression system: Escherichia coli