PDBe 4fl2

X-ray diffraction
2.19Å resolution

Structural and Biophysical Characterization of the Syk Activation Switch

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase SYK Chain: A
Molecule details ›
Chain: A
Length: 636 amino acids
Theoretical weight: 72.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P43405 (Residues: 1-635; Coverage: 100%)
Gene name: SYK
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 62.562Å b: 70.722Å c: 76.369Å
α: 90° β: 103.84° γ: 90°
R-values:
R R work R free
0.184 0.184 0.228
Expression system: Trichoplusia ni