PDBe 4ewr

X-ray diffraction
1.5Å resolution

X-ray structure of WDR5-SETd1a Win motif peptide binary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 23-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Histone-lysine N-methyltransferase SETD1A Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15047 (Residues: 1488-1501; Coverage: 1%)
Gene names: KIAA0339, KMT2F, SET1, SET1A, SETD1A

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 78.494Å b: 98.659Å c: 80.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.198
Expression systems:
  • Escherichia coli
  • Not provided