PDBe 4ewq

X-ray diffraction
2.1Å resolution

Human p38 alpha MAPK in complex with a pyridazine based inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Grum-Tokars V, Minasov G, Roy S, Schavocky J, Winsor J, Watterson DM, Anderson WF, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 44.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 65.257Å b: 74.276Å c: 76.815Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.229
Expression system: Escherichia coli