PDBe 4eo7

X-ray diffraction
1.45Å resolution

Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid differentiation primary response protein MyD88 Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99836 (Residues: 157-296; Coverage: 47%)
Gene name: MYD88
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 34.876Å b: 56.81Å c: 66.664Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.208
Expression system: Escherichia coli BL21(DE3)