PDBe 4e4v

X-ray diffraction
2.53Å resolution

The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.

Released:
Source organism: Homo sapiens
Entry authors: Hang PC, Miknis ZM, Franke WA, Umland TC, Schultz LW

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin subunit alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 485 amino acids
Theoretical weight: 52.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P52292 (Residues: 70-529; Coverage: 87%)
Gene names: KPNA2, RCH1, SRP1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P43212
Unit cell:
a: 143.52Å b: 143.52Å c: 136.957Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.203
Expression system: Escherichia coli BL21