PDBe 4e0n

X-ray diffraction
1.65Å resolution

SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 14 amino acids
Theoretical weight: 1.93 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 621-628; Coverage: 1%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 68.96Å b: 25.44Å c: 53.54Å
α: 90° β: 120.12° γ: 90°
R-values:
R R work R free
0.211 0.209 0.255
Expression system: Not provided