PDBe 4dnl

X-ray diffraction
1.9Å resolution

Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A resolution

Released:
Source organism: Homo sapiens
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C alpha type Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17252 (Residues: 155-293; Coverage: 21%)
Gene names: PKCA, PRKACA, PRKCA
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P3221
Unit cell:
a: 58.035Å b: 58.035Å c: 88.714Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.186 0.23
Expression system: Escherichia coli